Ways to interface Windows Mobile devices with Windows Mobile Device Center include Bluetooth, USB, and for legacy purposes, Serial. Whenever a Windows Mobile device is connected, the Mobile Device Center pane pops up giving options to manage media and other files on the device, as well as control their settings. Synchronization with Windows Mail, Windows Calendar, Windows Contacts, Outlook Express, Outlook 2010 圆4 and any version of Outlook prior to Outlook 2003 is not supported. with Microsoft Office Outlook, Windows Mobile Device Center needs to be downloaded, which includes the additional drivers as well. For complete functionality including synchronization of tasks, calendar data, contacts, email etc. The base driver in Windows Vista allows browsing the device, copying files and syncing with Windows Media Player.

While Windows Vista has a base driver built-in to interface with Windows Mobile devices in Windows Explorer, Windows Mobile Device Center offers a front-end for users to integrate their data in multiple Windows applications. Other versions of Windows, such as Windows Server 2008 and Windows Server 2008 R2 can also be WMDC enabled. However, basic connectivity became available for these devices with the 6.1 version release. With the release of Windows Mobile Device Center, Pocket PC 2000 and Pocket PC 2002 operating systems were effectively phased out of full native support with Windows Vista. In February 2007, the first official release was made available for download, and in June 2007, Windows Mobile Device Center was updated to work with the Windows Mobile 6 operating system. The first public release was available in October 2006 as a beta version meant for use with Windows Vista RC1. Windows Mobile Device Center was written as a successor to the ActiveSync program that was previously used to synchronize Windows CE based devices with Windows operating systems prior to Windows Vista.

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